The Ketogenic Diet For The Treatment Of Childhood Epilepsy A Randomised Controlled Trial

The ketogenic diet has been widely and successfully used to treat children with drug resistant epilepsy since the 1920s. The aim of this study was to test the efficacy of the ketogenic diet in a randomised controlled trial.

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the ketogenic diet for the treatment of childhood epilepsy a randomised controlled trial always related to the Ketogenic Diet. The Ketogenic Diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.

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A randomized trial of classical and medium chain triglyceride ketogenic diets in the treatment of childhood epilepsy.

The ketogenic diet for the treatment of childhood epilepsy a randomised controlled trial. Ketogenic diet in the treatment of epilepsy in children under the age of 2 years. Neal eg1 chaffe h schwartz rh lawson ms edwards n fitzsimmons g whitney a cross jh. The project proposed is an open label randomised controlled multicentre clinical trial of children aged 3 months to 2 years of age with epilepsy who have failed to respond to two or more pharmacological treatments aed or corticosteroids comparing kd to further aed treatment.

Study protocol for a randomised controlled trial. The results were comparable to a similar randomized controlled trial of the ketogenic diet in children with refractory epilepsy neal et al 2008. However the high fat adequate protein low carbohydrate ketogenic diet was not first used for any of these purposes.

Many people use the ketogenic diet today to manage symptoms of diabetes lower triglycerides and lose body weight. Ketogenic diet in the treatment of epilepsy in children under the age of 2 years. Study protocol for a randomised controlled trial article pdf available in trials 181 december 2017 with 315.

Neal et al found that the median seizure frequency at 3 months expressed as a percentage of the baseline was 477 in the ketogenic diet and 106 in the control group. The ketogenic diet initially described by hugh conklin a michigan pediatrician is a high fat low carbohydrate and normal protein diet that has been used for the treatment of medically refractory childhood epilepsy since the 1920s. Instead doctors created it to help treat epilepsy in children.

145 children aged between 2 and 16 years who had at least daily seizures or more than seven. 145 children aged between 2 and 16 years who had at least daily seizures or more than seven seizures per week had failed to respond to at least two antiepileptic drugs and had not been treated previously with the ketogenic diet participated in a randomised controlled trial of its efficacy to control seizures. 1 although its use became less frequent with the introduction of anticonvulsant medications the diet has regained recognition over the past 15 to 20 years.

The aim of this study was to test the efficacy of the ketogenic diet in a randomised controlled trial.


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