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ketogenic diet side effects pubmed always related to the Ketogenic Diet. The Ketogenic Diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.
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Administering a ketogenic diet for a relatively longer period of time did not produce any significant side effects in the patients.
Ketogenic diet side effects pubmed. Why one might logically ask should the ketogenic diet not become the primary therapeutic option when the diagnosis of epilepsy is first established. For phenytoin one study failed to show a decrease in femur bmd whereas another study reported a decrease in total body and spine bmd but only with the use of phenytoin for 2 years. A systematic search of pubmed resulted in 14 papers that described changes in bmd in children on aeds.
After all dietary manipulation largely eliminates the need for drugs with all of their potential side effects and surgery with its attendant risks including possible brain damage and death. Number of items. Benefits and adverse effects of ketogenic diets.
Moreover there is some evidence that ketogenic diets may have positive effects on mood in overweight subjects 4849. The ketogenic diet was originally developed in 1924 to treat epilepsy 5 but other more recently discovered benefits include weight loss and reversalcontrol of type 2 diabetes 6use of ketogenic diets in weight management has gained tremendous popularity but it has also generated several controversies. Even if during the very early phase of a ketogenic diet the first 4 or 5 days subjects may sometimes complain of lethargy 5051 this effect passes rapidly and subjects subsequently report an improved mood 444849.
Therefore the present study confirms that it is safe to use a ketogenic diet for a longer period of time than previously demonstrated. All studies reported participants dropping out due to lack of improvement in seizures and poor tolerance of the diet. The shortterm side effects of ketogenic diets included diarrhoea constipation and vomiting.
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