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Ketogenic Diet And Epilepsy Mechanism

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The diet forces the body to burn fats rather than carbohydratesnormally the carbohydrates contained in food are converted into glucose which is then transported around the body and is particularly important in fueling. The ketogenic diet is a high fat adequate protein low carbohydrate diet that in medicine is used primarily to treat difficult to control refractory epilepsy in children.

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ketogenic diet and epilepsy mechanism always related to the Ketogenic Diet. The Ketogenic Diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.

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A ketogenic diet is an important therapy used in the control of drug refractory seizures.

Ketogenic diet and epilepsy mechanism. The classic ketogenic diet is a special high fat low carbohydrate diet that helps to control seizures in some people with epilepsy. Whats important when it comes to ketosis and epilepsy is the mechanisms by which the ketogenic diet helps alleviate seizures is those with this chronic disorder. High fat low carbohydrate diets known as ketogenic diets have been used as a non pharmacological treatment for refractory epilepsy.

Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50 reduction in seizure frequency which is considered to be clinically relevant. Show full abstract forms of seizure control however the mechanism remains unknown. Despite nearly a century of use the mechanisms underlying its clinical efficacy remain unknown.

A ketogenic diet is a high fat moderate protein and very low carb diet. Lets take a look at some ideas about why its been successful in some epilepsy patients. Aeds work by targeting neurons and altering the chemical signals they produce.

Dominic dagostino kd epilepsy mechanisms. In this review we present one intersecting view of how the kd may exert its anticonvulsant activity against the backdrop of several seemingly disparate mechanistic theories. Management of epilepsy with ketogenic diet.

The ketogenic diet is a specialized diet that involves highly restricted intake of carbohydrates and proteins and a high proportion of fat consumption. The ketogenic diet kd is a high fat low carbohydrate adequate protein diet that has been employed as a treatment for medically refractory epilepsy for over 90 years. It has proven to be used in the treatment of.

Because the ketogenic diet works when medicines fail it appears that the diets mechanisms of action are different than those of anti epileptic drugs. A key mechanism of this treatment is thought to be the generation of ketones which provide brain cells neurons and astrocytes with an energy source that is more efficient than glucose resulting in beneficial downstream metabolic changes such as increasing. The diet is very high fat moderate protein very low.

The ketogenic diet kd is a broadly effective treatment for medically refractory epilepsy. 1 this alternative therapy was originally designed to mimic the biochemical changes associated with fasting a treatment reported anecdotally over millennia to control seizure activity. Doctors usually recommend the ketogenic diet for children whose seizures have not responded to several different seizure medicines.


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