This phase i trial studies the side effects of a ketogenic diet in treating patients with stage ii iii pancreatic cancer undergoing chemoradiation therapy. The ketogenic diet or keto for short is a very low carbohydrate low sugar glucose diet.
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ketogenic diet cancer trial always related to the Ketogenic Diet. The Ketogenic Diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.
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Saw decreased tumor weight and improved cachexia in mice with colon adenocarcinoma xenografts eating a ketogenic diet.
Ketogenic diet cancer trial. The trial was conducted over a period of 12 weeks. Since then a study protocol was. Recently ketogenic diets have been studied as an adjuvant to cancer therapy in both animal models and human case reports.
The ketogenic or keto diet consists of foods that are high in fat moderate to low in protein and very low in carbohydrates. Ketogenic diets have a very low level of carbohydrates sugars and may have good or bad effects during chemotherapy and radiation therapy. A low carbohydrate ketogenic approach has been previously studied in small samples of patients with other types of cancer and also proposed for prostate cancer patients.
In brief a ketogenic diet is a high fat low carbohydrate diet that mimics the metabolic state of long term fasting. Normally the human body runs on glucose from carbohydrates for fuel but when following a ketogenic diet the body switches to using ketones from fatty acids. Kd and radiation for pancreatic cancer.
The ketogenic diet consisted of 70 fat 25 protein and 5 carbohydrates whereas the american cancer society diet was high fiber and low fat. Although there is speculation that a keto diet can help cancer patients starve cancer cells by preventing the cells from using glucose for energy and growth there is no concrete evidence that a keto diet will benefit cancer patients in particular. As observed in previous trials with ketogenic diets in adults.
Pilot study of a metabolic nutritional therapy for the management of primary brain tumors. Patients chosen must be diagnosed with advanced or metastatic cancer of the following tumor types colorectal prostate brain breast pancreatic hepatobiliary melanoma sarcoma non small cell small cell lung genitourinary cancersall participants will be assigned to a ketogenic diet. Ketogenic diets in cancer therapy.
Kd for head and neck cancer. As early as 1987 tisdale et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer.
Kd and chemotherapy for lung cancer. A pilot trial. Care oncology clinic repurposing drugs for cancer therapy ketogenic diet for advanced cancer.
Except for two preliminary reports 2654 no protocol was available on how to perform an lchf or ketogenic diet study with cancer patients. They randomly assigned the participants to either a ketogenic diet or the american cancer society diet. The midatlantic epilepsy and sleep center in bethesda maryland has a trial of the ketogenic diet as adjunctive treatment given after surgery in brain cancers that relapse.
Majority of the ketogenic diet trials are studying brain tumors.
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