Ketogenic Diet And Cancer Pubmed

As such the concept of a ketogenic diet kd in cancer emerged as a metabolic therapy ie targeting cancer cell metabolism rather than a dietary approach. 2654 no protocol was available on how to perform an lchf or ketogenic diet study with cancer patients.

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ketogenic diet and cancer pubmed always related to the Ketogenic Diet. The Ketogenic Diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures. Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective. Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.

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Recently ketogenic diets have been studied as an adjuvant to cancer therapy in both animal models and human case reports.

Ketogenic diet and cancer pubmed. Ketogenic diet in combination with voluntary exercise impacts markers of hepatic metabolism and oxidative stress in male and female wistar rats. However the question remains which conclusions can be drawn from the available human data thus far concerning the safety and efficacy of kds for cancer patients. The therapeutic mechanisms of action of this high fat moderate to low protein and very low carbohydrate diet may potentially influence cancer treatment and prognosis.

Since then a study protocol was published by fine et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer. Ketogenic diets kds have gained popularity among patients and researchers alike due to their putative anti tumor mechanisms.

A pilot trial. Appl physiol nutr metab. Ketogenic diets in cancer therapy.

As early as 1987 tisdale et al. Saw decreased tumor weight and improved cachexia in mice with colon adenocarcinoma xenografts eating a ketogenic diet. However patients with locally advanced nsclc and pancreatic cancer receiving concurrent radiotherapy and chemotherapy had suboptimal compliance to the oral ketogenic diet and thus poor tolerance.

And four clinical trials were registered in the clinical trials database. The preclinical experiments demonstrate that a ketogenic diet increases radiation sensitivity in a pancreatic cancer xenograft model.


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